Protein Modification Reagents
Medchemexpress LLC Propargyl-PEG6-N3 | 1198080-03-3 | 100 MG
Propargyl-PEG6-N3 is a PEG-based PROTAC linker employed in the synthesis of PROTACs. It functions as a versatile click chemistry reagent, featuring an Azide group. This group readily participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) when combined with molecules containing Alkyne groups. Furthermore, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules that possess DBCO or BCN groups, offering flexible synthetic pathways.
- PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Click chemistry reagent.
- Contains an Azide group.
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with Alkyne groups.
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
Medchemexpress LLC DSPE-PEG2-mal | 1915739-87-5 | 99.9% | 1058.37 | C55H100N3O14P | 5 MG
DSPE-PEG2-mal is a PEG-based maleimide-functionalized linker that couples a DSPE lipid moiety to a short PEG spacer terminated with a maleimide group. It is intended for thiol-directed conjugation in the synthesis of PROTACs and other bioconjugates, providing a lipid anchor with improved solubility and membrane association. Manufacturer-reported properties include high purity, molecular weight ~1058.37, and formula C55H100N3O14P.
- Provides a maleimide terminus for thiol-specific conjugation.
- Contains a DSPE lipid moiety for membrane anchoring.
- Includes a short PEG spacer to improve solubility and reduce steric hindrance.
- High reported purity suitable for research applications.
- Solid, white to off-white appearance for convenient handling.
Medchemexpress LLC HS-PEG5-CH2CH2NH2 hydrochloride | 1446256-16-1 | 98.0% | C12H28ClNO5S | 10MG
HS-PEG5-CH2CH2NH2 hydrochloride is a thiol-terminated PEG5 linker supplied as the hydrochloride salt, intended for synthesis of PROTACs and other bioconjugates. It provides a short, flexible spacer with terminal thiol and amine groups for versatile conjugation chemistries.
- Thiol-terminated PEG5 linker for conjugation chemistries.
- Terminal ethyleneamine available as hydrochloride salt.
- Short, flexible spacer suitable for PROTAC design.
- High purity (98.0%) for consistent synthetic performance.
- Compatible with common bioconjugation reactions.
Medchemexpress LLC Cyanine 5-polyethylene glycol3-TCO | 99.2% | 845.55 | C49H69ClN4O6 | 10 MG
Cy5-PEG3-TCO is a Cy5-derived fluorescent probe bearing a three-unit polyethylene glycol (PEG3) spacer and a trans-cyclooctene (TCO) functional group. It is designed for bioorthogonal labeling via inverse electron-demand Diels-Alder (iEDDA) reactions with tetrazine-functionalized partners and is supplied as a solid for laboratory use.
- Cyanine 5 fluorescent core for near-infrared imaging
- PEG3 spacer improves solubility and reduces steric hindrance
- TCO group enables rapid iEDDA click chemistry with tetrazines
- High purity (99.2%) suitable for labeling applications
- Soluble in DMSO (≈16.67 mg/mL); may require ultrasonic
- Stored sealed away from moisture and light at 4°C (solid)
Medchemexpress LLC M-PEG5-azide | 1202681-04-6 | 50 MG
M-PEG5-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This click chemistry reagent features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Functions as a PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Acts as a click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing molecules
Medchemexpress LLC DNP-PEG4-acid | 858126-76-8 | 100 MG
DNP-PEG4-acid is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs are compounds that exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins, consisting of two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
- Relevant for cancer and cancer targeted therapy research
Medchemexpress LLC Acid-C2-PEG4-C2-NHS ester | 1343476-41-4 | 98.0% | 25 MG
Acid-C2-PEG4-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- One ligand for an E3 ubiquitin ligase and the other for the target protein
- Leverages the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thp-peg4-pyrrolidine(n-me)-ch2oh | 2378261-81-3 | 95.0% | 25 MG
THP-PEG4-Pyrrolidine(N-Me)-CH2OH is a PEG-based PROTAC linker. It can be utilized in the synthesis of PROTAC K-Ras Degrader-1. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins, typically consisting of two different ligands connected by a linker; one for an E3 ubiquitin ligase and the other for the target protein.
- Peg-based PROTAC linker.
- Used in the synthesis of PROTAC K-Ras degrader-1.
- Enables PROTACs to leverage the ubiquitin-proteasome system.
- PROTAC K-Ras degrader-1 shows ≥70% degradation efficacy in SW1573 cells.
Medchemexpress LLC Biotin-PEG4-acid | 721431-18-1 | 97.0% | 1 G
Biotin-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed to harness the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. They consist of two distinct ligands connected by a linker, with one ligand targeting an E3 ubiquitin ligase and the other targeting a protein of interest.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Facilitates selective degradation of target proteins
- Engages the ubiquitin-proteasome system
Medchemexpress LLC Biotin-PEG2-azide | 1910803-72-3 | 97.0% | 1 G
Biotin-PEG2-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that enables it to undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with Alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains an Azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC Amino-PEG2-CH2CH2-SH (hydrochloride) | 3037676-58-4 | 95.0% | 201.71 g/mol | C6H16ClNO2S | 5 MG
Amino-PEG2-CH2CH2-SH (hydrochloride) is a PEG-based bifunctional linker for synthesis of PROTACs and conjugates. It features a primary amino group and a terminal thiol separated by a two-unit PEG spacer, supplied as the hydrochloride salt to aid stability and handling.
- Provides primary amino and terminal thiol functional groups for conjugation
- Two-unit PEG spacer offers flexibility and solubility
- Hydrochloride salt form improves stability and handling
- High purity suitable for synthetic applications
- Available in small milligram pack sizes for research use
Medchemexpress LLC Tos-PEG4-NH-Boc (PROTAC Linker 7) | 1246999-33-6 | >98.0% | 100 MG
Tos-PEG4-NH-Boc (PROTAC Linker 7) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based linker.
- Used in the synthesis of PROTACs.
- Connects two different ligands.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
Medchemexpress LLC DBCO-PEG4-DBCO | 2182601-68-7 | 97.4% | 250 MG
DBCO-PEG4-DBCO is a versatile PEG-based PROTAC linker and a cleavable ADC linker. It is utilized in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This compound functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.
- Used in PROTAC synthesis
- Cleavable ADC linker
- Click chemistry reagent
- Features a DBCO group
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC)
- Reacts with azide groups
Medchemexpress LLC Tos-PEG4-THP | 86259-89-4 | 250 MG
Tos-PEG4-THP is a PEG-based PROTAC linker designed for use in the synthesis of PROTAC K-Ras Degrader-1. PROTACs are compounds that leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins, featuring two different ligands connected by a linker: one for an E3 ubiquitin ligase and another for the target protein.
- Used in PROTAC synthesis
- Targeted for PROTAC linkers and PROTAC pathway
- Storage at -20°C, under nitrogen
- Solvent storage at -80°C for 6 months; -20°C for 1 month (under nitrogen)
- Soluble in H2O at 100 mg/mL