Protein Modification Reagents
Medchemexpress LLC N3-PEG4-C2-NHS ester | 944251-24-5 | MFCD13184948 | >90% | 388.37 g/mol | C15H24N4O8 | 50 MG
N3-PEG4-C2-NHS ester is an azide-functionalized, non-cleavable polyethylene glycol (PEG) linker containing an N-hydroxysuccinimide (NHS) ester for amine coupling and an azide (N3) group for click chemistry applications such as antibody-drug conjugate (ADC) synthesis and bioconjugation.
- Azide-functionalized 4-unit PEG linker suitable for bioconjugation.
- N-hydroxysuccinimide (NHS) ester for efficient amine coupling.
- Compatible with copper-catalyzed and strain-promoted azide-alkyne cycloaddition.
- High solubility in DMSO; stock solutions commonly prepared per datasheet guidance.
- Storage recommendations: pure form -20°C up to 3 years; in solvent -80°C for 6 months or -20°C for 1 month.
![Medchemexpress LLC Propanoic acid, 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]- | 663921-15-1 | MFCD11041129 | 99.9% | 265.30 g/mol | C11H23NO6 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202942.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]- | 663921-15-1 | MFCD11041129 | 99.9% | 265.30 g/mol | C11H23NO6 | 100 MG
NH2-PEG4-CH2CH2COOH is a cleavable four-unit polyethylene glycol (PEG) linker with an N-terminal amine and a terminal propanoic acid, designed for use in antibody-drug conjugate (ADC) and PROTAC synthesis.
- Cleavable 4-unit PEG linker.
- Amine functional group for conjugation.
- Terminal carboxylic acid for coupling reactions.
- High purity (99.9%).
- Molecular weight 265.30 g/mol.
- Soluble in DMSO.
- Available as a 100 MG pack.
Medchemexpress LLC DBCO-PEG4-DBCO | 2182601-68-7 | 97.4% | 810.93 | C48H50N4O8 | 10 MG
DBCO-PEG4-DBCO is a PEG-based bifunctional linker bearing two dibenzocyclooctyne (DBCO) groups. It is used as a click chemistry reagent for strain-promoted alkyne-azide cycloaddition (SPAAC) and as a PEG linker in PROTAC and antibody-drug conjugate (ADC) synthesis.
- Click chemistry reagent enabling SPAAC with azide-functionalized partners.
- Provides a PEG4 spacer to improve solubility and linker flexibility.
- High solubility in DMSO; manufacturer provides in vitro and in vivo formulation protocols.
- Typical purity around 97.4% and appears as a white to yellow solid.
- Suitable for use in PROTAC and ADC synthesis workflows.
Medchemexpress LLC Amino-PEG4-GGFG-Dxd | 2879227-88-8 | 1088.14 g·mol⁻1 | C53H66FN9O15 | 5 MG
Amino-PEG4-GGFG-Dxd is a drug-linker conjugate intended for use in antibody-drug conjugate (ADC) synthesis. It couples a DXd (deruxtecan) payload to a GGFG peptide-based linker via a PEG4 spacer and provides an amino functional handle for conjugation to antibodies.
- drug-linker conjugate for ADC synthesis
- contains a DXd payload linked via a cleavable GGFG peptide linker
- includes a PEG4 spacer to improve solubility and spacing
- features an amino functional handle for conjugation chemistry
- available in small milligram quantities for research use
- molecular weight 1088.14 g·mol⁻1, formula C53H66FN9O15
Medchemexpress LLC M-PEG5-CH2CH2COOH | 1347750-72-4 | MFCD20926383 | ≥95.0% | 324.37 g/mol | C14H28O8 | 250 MG
m-PEG5-CH2CH2COOH is a methoxy-capped PEG5 propionic acid linker used as a PEG spacer in the synthesis of PROTACs and other bioconjugates. Supplied as a purified solid reagent, it is intended for research use in conjugation and organic synthesis.
- High purity suitable for research applications.
- PEG5 spacer provides flexible linkage and improved solubility.
- Carboxylic acid terminus enables amide or ester coupling reactions.
- Available in multiple pack sizes for scale flexibility.
- Provided with datasheet, SDS, and COA for quality assurance.
Medchemexpress LLC Endo-BCN-PEG4-acid | 1881221-47-1 | 99.3% | 441.52 | C22H35NO8 | 10 MG
endo-BCN-PEG4-acid is a cleavable four-unit polyethylene glycol (PEG) linker containing a bicyclononyne (BCN) group that enables strain-promoted alkyne-azide cycloaddition (SPAAC). It is used as a copper-free click chemistry reagent for bioconjugation, including antibody-drug conjugate and PROTAC linker synthesis.
- Cleavable 4-unit PEG linker facilitating conjugation.
- BCN moiety enables copper-free SPAAC with azide groups.
- Molecular weight 441.52 and formula C22H35NO8.
- CAS number 1881221-47-1; high purity for research use.
- Storage recommendations include low-temperature conditions for long-term stability.
- Typical applications: ADC linker chemistry, bioconjugation, and PROTAC synthesis.
Medchemexpress LLC Cyanine 5-polyethylene glycol3-TCO | 99.2% | 845.55 | C49H69ClN4O6 | 10 MG
Cy5-PEG3-TCO is a Cy5-derived fluorescent probe bearing a three-unit polyethylene glycol (PEG3) spacer and a trans-cyclooctene (TCO) functional group. It is designed for bioorthogonal labeling via inverse electron-demand Diels-Alder (iEDDA) reactions with tetrazine-functionalized partners and is supplied as a solid for laboratory use.
- Cyanine 5 fluorescent core for near-infrared imaging
- PEG3 spacer improves solubility and reduces steric hindrance
- TCO group enables rapid iEDDA click chemistry with tetrazines
- High purity (99.2%) suitable for labeling applications
- Soluble in DMSO (≈16.67 mg/mL); may require ultrasonic
- Stored sealed away from moisture and light at 4°C (solid)
![Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | 98.5% | 406.39 g·mol⁻1 | C19H22N2O8 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000204110.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | 98.5% | 406.39 g·mol⁻1 | C19H22N2O8 | 100 MG
Ald-Ph-amido-PEG2-C2-NHS ester is a noncleavable two-unit polyethylene glycol (PEG) linker designed for antibody-agent conjugation (ADC) research. It features an NHS-activated ester for amine coupling and an aldehyde-phenyl functional handle for orthogonal conjugation chemistry.
- Provides a noncleavable 2-unit PEG spacer for conjugation
- NHS ester activated for efficient coupling to primary amines
- Aldehyde-phenyl functional group for orthogonal conjugation chemistry
- High purity suitable for research applications
- Available in multiple pack sizes and formats, including 100 MG
Medchemexpress LLC NH2-C5-PEG4-N3-L-lysine-PEG3-N3 | 99.4% | 619.71 g/mol | C25H49N9O9 | 5 MG
A cleavable 7-unit polyethylene glycol (PEG) linker with an azide functional group used for antibody-drug conjugate synthesis and bioconjugation via click chemistry.
- Cleavable 7-unit PEG linker suitable for ADC construction.
- Azide functional group enabling copper-catalyzed and strain-promoted azide-alkyne cycloaddition.
- High purity (99.4%) for research-grade applications.
- High aqueous solubility (≥100 mg/mL) for easy handling and formulation.
- Stable as a solid at -20 °C; defined storage recommendations for solutions.
Medchemexpress LLC 4,7,10,13,16,19-hexaoxaheneicosanoic acid, 2,5-dioxo-1-pyrrolidinyl ester | 1599472-25-9 | MFCD20926374 | 98.0% | 530.52 | C23H34N2O12 | 100 MG
Mal-PEG6-NHS ester is a non-cleavable antibody-drug conjugate (ADC) linker composed of a maleimide group, a six-unit polyethylene glycol (PEG6) spacer, and an N-hydroxysuccinimide (NHS) ester that enables thiol and amine bioconjugation.
- Non-cleavable ADC linker suitable for antibody conjugation.
- Contains maleimide and NHS ester reactive groups.
- PEG6 spacer increases hydrophilicity and solubility.
- Purity 98.0% (NMR) and molecular weight ~530.52 g/mol.
- Soluble in DMSO at 100 mg/mL; may require sonication.
- Store at -20 °C and protect from light; stock solutions: -80 °C (6 months), -20 °C (1 month).
- CAS number 1599472-25-9.
Medchemexpress LLC Mal-PEG4-VC-PAB-DMEA-PNU-159682 | 2259318-52-8 | 1559.62 | C74H98N10O27 | 5 MG
Mal-PEG4-VC-PAB-DMEA-PNU-159682 is a cleavable antibody-drug conjugate (ADC) drug-linker conjugate that couples a maleimide-PEG4 linker to the cytotoxic payload DMEA-PNU-159682 for use in ADC research and synthesis. It is supplied in small milligram pack sizes for preclinical research applications.
- Cleavable maleimide-PEG4 linker enabling thiol conjugation.
- Valine-citrulline (vc) dipeptide linker with PABC self-immolative spacer.
- Includes DMEA-PNU-159682 cytotoxic payload for ADC development.
- Supplied as a small-scale mg quantity suitable for research use.
- Molecular weight 1559.62 and molecular formula C74H98N10O27.
- CAS number 2259318-52-8 for unambiguous identification.
Sigma Aldrich Fine Chemicals Biosciences Collagenase from Clostridium histolyticum Sigma Blend Type H, >=1.0 FALGPA units/mg solid | 9001-12-1 | MFCD00130830 | 100MG
Collagenase from Clostridium histolyticum Sigma Blend Type H, >=1.0 FALGPA units/mg solid | 9001-12-1 | MFCD00130830 | 100MG
